This guide is an introduction to the research process that, while not being an exhaustive list of information resources available, should be helpful in getting started in your research about gene therapy. Below you will find pointers to suggested research terms about gene therapy, materials in the library catalog about gene therapy, websites relevant to gene therapy, and links to library databases that contain information about gene therapy. Please use our email reference service, contact us at (310) 434-4254, or visit us in the library at the reference desk if you need further assistance.
Suggested Research Terms
One of the really helpful things when searching for information about a topic is a short list of terms related to a topic. We think the following terms will help with your research about gene therapy:
- gene splicing
- genome
- genetic diseases
Materials in the library catalog related to gene therapy
We have the following materials in the library catalog related to gene therapy:
Websites on gene therapy
The following websites will help you with your research on gene therapy:
American Society of Gene Therapy (ASGT)
ASGT, an organization dedicated to informing the media and the public about gene therapy news events and ongoing research, defines gene therapy and its possible uses as "an approach to treating disease by either modifying the expressions of an individual.s genes or correction of abnormal genes. By administration of DNA rather than a drug, many different diseases are currently being investigated as candidates for gene therapy. These include cystic fibrosis, cardiovascular disease, infectious diseases such as AIDS and cancer."
ASGT, an organization dedicated to informing the media and the public about gene therapy news events and ongoing research, defines gene therapy and its possible uses as "an approach to treating disease by either modifying the expressions of an individual.s genes or correction of abnormal genes. By administration of DNA rather than a drug, many different diseases are currently being investigated as candidates for gene therapy. These include cystic fibrosis, cardiovascular disease, infectious diseases such as AIDS and cancer."
Human Gene Therapy and the Role of the Food and Drug Administration
The U. S. Food and Drug Administration (FDA) defines human gene therapy and its advantages as "the replacement of a person's faulty genetic material with normal genetic material to treat or cure a disease or abnormal medical condition. Over time and with proper oversight, human gene therapy could become an effective weapon in modern medicine's arsenal to help fight diseases such as cancer, diabetes, high blood pressure and heart disease. Also, for patients with presently incurable diseases, such as cystic fibrosis, hemophilia A and B, and other genetic disorders, human gene therapy may offer some hope of a cure, or at least a measure of relief." The role of the FDA in this endeavor includes "protecting the health of U.S. citizens by ensuring that drugs, medical devices, and biological products are safe and effective before they are used by doctors, nurses, other health care professionals, hospitals and consumers."
The U. S. Food and Drug Administration (FDA) defines human gene therapy and its advantages as "the replacement of a person's faulty genetic material with normal genetic material to treat or cure a disease or abnormal medical condition. Over time and with proper oversight, human gene therapy could become an effective weapon in modern medicine's arsenal to help fight diseases such as cancer, diabetes, high blood pressure and heart disease. Also, for patients with presently incurable diseases, such as cystic fibrosis, hemophilia A and B, and other genetic disorders, human gene therapy may offer some hope of a cure, or at least a measure of relief." The role of the FDA in this endeavor includes "protecting the health of U.S. citizens by ensuring that drugs, medical devices, and biological products are safe and effective before they are used by doctors, nurses, other health care professionals, hospitals and consumers."
Genetics Home Reference: Your Guide to Understanding Genetic Conditions
This National Library of Medicine site provides "consumer information about genetic conditions and the genes responsible for those conditions." A searchable and browsable directory includes FAQs and links to related resources about specific genes and conditions. The site also offers a basic explanation of how genes work; a glossary; and information about genetic testing, gene therapy, and the Human Genome Project.
This National Library of Medicine site provides "consumer information about genetic conditions and the genes responsible for those conditions." A searchable and browsable directory includes FAQs and links to related resources about specific genes and conditions. The site also offers a basic explanation of how genes work; a glossary; and information about genetic testing, gene therapy, and the Human Genome Project.
American Medical Association Current Topic Page: Gene Therapy
This page provides a brief, clear introduction to the topic, addressing how gene therapy works and which diseases can be treated.
This page provides a brief, clear introduction to the topic, addressing how gene therapy works and which diseases can be treated.
National Institutes of Health Bioethics Resources on the Web
Provides annotated lists with links to websites on various topics in bioethics.
Provides annotated lists with links to websites on various topics in bioethics.
Human Gene Therapy: Harsh Lessons, High Hopes
This U. S. Food and Drug Administration (FDA) September 2000 magazine article examines the progress-to-that-date of gene therapy and the problems that had been encountered: "In the 10 years since that first genetic treatment on Sept. 14, 1990, the hyperbole has exceeded the results. Worldwide, researchers launched more than 400 clinical trials to test gene therapy against a wide array of illnesses. Surprisingly, cancer has dominated the research. Even more surprising, little has worked."
This U. S. Food and Drug Administration (FDA) September 2000 magazine article examines the progress-to-that-date of gene therapy and the problems that had been encountered: "In the 10 years since that first genetic treatment on Sept. 14, 1990, the hyperbole has exceeded the results. Worldwide, researchers launched more than 400 clinical trials to test gene therapy against a wide array of illnesses. Surprisingly, cancer has dominated the research. Even more surprising, little has worked."
Gene Therapy Clinical Trials Worldwide
Provided by the Journal of Gene Medicine, this site includes .charts and tables showing the number of approved, ongoing or completed clinical trials worldwide.. You can search the site for trial country, disease category, vector used, gene type, and more.
Provided by the Journal of Gene Medicine, this site includes .charts and tables showing the number of approved, ongoing or completed clinical trials worldwide.. You can search the site for trial country, disease category, vector used, gene type, and more.
Library Databases relevant to gene therapy
The following Santa Monica College Library online databases may contain material relevant to gene therapy. Databases may include magazine, newspaper and journal articles. Please note: you must be a Santa Monica College student, faculty or staff member to use these services.
Health Source
Health Source: Consumer Edition offers information on many health topics including the medical sciences, food sciences and nutrition, childcare, sports medicine and general health. Has full text for nearly 300 journals.
Health Source: Consumer Edition offers information on many health topics including the medical sciences, food sciences and nutrition, childcare, sports medicine and general health. Has full text for nearly 300 journals.
CINAHL Plus with Full Text
Provides complete coverage of the professional literature in nursing, 14 allied health disciplines and health sciences librarianship. In addition, there are over 560 journals in full text.
Provides complete coverage of the professional literature in nursing, 14 allied health disciplines and health sciences librarianship. In addition, there are over 560 journals in full text.
Science Full Text Select
Coverage includes popular science magazines as well as professional journals. Also covers The New York Times Science Section. Full text coverage begins in January 1995.
Coverage includes popular science magazines as well as professional journals. Also covers The New York Times Science Section. Full text coverage begins in January 1995.
Academic Search Premier, MasterFile Premier
Academic Search Premier and MasterFile Premier provide full text for over 6200 periodicals including full text for more than 3,500 peer-reviewed journals. Coverage spans virtually every area of academic study and offers information dating as far back as 1975.
Academic Search Premier and MasterFile Premier provide full text for over 6200 periodicals including full text for more than 3,500 peer-reviewed journals. Coverage spans virtually every area of academic study and offers information dating as far back as 1975.
National Newspapers (1985- current)
Local, regional and national news coverage from selected newspapers, including the Los Angeles Times, New York Times, Washington Post, Wall Street Journal, Atlanta Journal-Constitution, Boston Globe, Chicago Tribune, Denver Post, USA Today, Christian Science Monitor.
Local, regional and national news coverage from selected newspapers, including the Los Angeles Times, New York Times, Washington Post, Wall Street Journal, Atlanta Journal-Constitution, Boston Globe, Chicago Tribune, Denver Post, USA Today, Christian Science Monitor.
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